Question 1

Is DHHB a powerful antioxidant?

Accepted Answer

Honokiol and its derivatives also act as a powerful antioxidant, lowering oxidative stress and in the brain and inflammation throughout the body.

Question 2

How does DHH-B work?

Accepted Answer

Honokiol is a poly-phenolic compound studied for its neuroprotective properties by a variety of mechanisms. Its therapeutic potential has been researched in anxiety, pain, cerebrovascular injury, epilepsy, and cognitive disorders. It has historically been used in Southeast Asia. Still, it has become more widely studied because of its pleiotropic (secondary and tertiary) effects.

Question 3

Does DHHB relieve stress?

Accepted Answer

DHH-B supplement has also been researched for its ability to inhibit an overactive adrenal gland, lowering the hormone associated with stress and agitation

Question 4

Does D-HHB help with sleep and anxiety?

Accepted Answer

DHH-B for anxiety is ever popular. With an increased awareness of the unwanted side effects of benzodiazepines, DHH-B has been used by many to decrease daytime anxiety. This powerful natural anti-anxiety medicine also works well to facilitate sleep.

Question 5

What are benefits of DHH-B?

Accepted Answer

DHH-B (Dihydrohonokiol-B) is a natural derivative that has been researched for its benefits on mood and anxiolytic effects.

Question 6

Does DHHB create a a calming effect?

Accepted Answer

Like other magnolia bark extracts, DHH-B boosts GABA, a neurotransmitter that produces a calming effect. GABA soothes those neural properties that facilitate agitation, turmoil, and upheaval.

Question 7

Is DHHB Better then benzodiazepines?

Accepted Answer

Benzodiazepines, are some of the most commonly prescribed medications in the United States. These anxiolytics have many well-known side effects, including motor function, blurred vision, confusion, constipation, dizziness, drowsiness, memory problems, nausea, and many more.

In addition to abuse and dependence, other documented risks associated with benzodiazepine use include:

Motor vehicle accidents. Driving while on benzodiazepines increases the risk of crashes to about the same as the risk of driving with a blood-alcohol level between 0.050% and 0.079% (1) (more than 0.08% is illegal in all states).
Hip fracture. When taking benzodiazepines, the risk of hip fracture in older people increases by around 50%(1).
Distinctly different from benzodiazepines, DHH-B causes no effect on motor activity or muscle engagement and has been used to wean patients off benzodiazepines. As such, DHH-B may be a suitable option for people struggling with motor systems side effects of benzodiazepines.

https://www.aafp.org/pubs/afp/issues/2013/0815/p224.html#afp20130815p224-b9

Question 8

DHH-B activates cannabinoid receptors

Accepted Answer

According to studies, DHH-B also activates cannabinoid receptors throughout the body. These receptors have a hand in immune systems, pain relief, and disease prevention, so activation reduces inflammation, relieves pain, and elevates mood.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4027495/
Magnolia Extract, Magnolol, and Metabolites: Activation of Cannabinoid CB2 Receptors and Blockade of the Related GPR55

Question 9

A honokiol-enriched Magnolia bark extract possesses anxiolytic-like activity

Accepted Answer

A honokiol-enriched Magnolia bark extract possesses anxiolytic-like activity with neuroprotective effect through the modulation of CB1 receptor.
Abstract
Objectives: The exposure of neurons to an excessive excitatory stimulation induces the alteration of the normal neuronal function. Mood disorders are among the first signs of alterations in the central nervous system function. Magnolia officinalis bark extract has been extensively used in the traditional medicine systems of several countries, showing several pharmacological activities. Honokiol, the main constituent of M. officinalis, is a GABA modulator and a CB1 agonist, which is deeply investigated for its role in modulating mood disorders.

Methods: Thus, we evaluated the possible neuroprotective effect of a standardized M. officinalis bark extract (MOE), enriched in honokiol, and its effect on animal mood behavioural tests and in an in vitro model of excitotoxicity.

Key findings: MOE showed neuroprotective effect using SH-SY5Y cells, by normalizing brain-derived neurotrophic factor release. Then, we tested the effect of MOE in different behavioural tests evaluating anxiety and depression and we observed a selective anxiolytic-like effect. Finally, we confirmed the involvement of CB1 in the final effect of MOE by the co-administration of the CB1 antagonist, AM251.

Conclusion: These results suggest that MOE could be considered an effective and safe anxiolytic candidate with neuroprotective activity.

Keywords: Magnolia officinalis; CB1; Honokiol; anxiety; neuroprotection.

https://pubmed.ncbi.nlm.nih.gov/33950239/

Question 10

What is DHH-B used for?

Accepted Answer

Used in ancient Asian medicine, the extracts of the magnolia tree’s bark have been touted for their curative and calming effects for centuries. They are now being researched in western culture as well.

DHH-B is approximately 2,000% stronger than the often-mentioned extract, honokiol, for those familiar with magnolia bark extract.

Question 11

Does magnolia bark increase GABA?

Accepted Answer

The active ingredients in the extracts have been identified as the bi-phenolic isomers magnolol and honokiol. These compounds were shown to enhance the activity of GABA receptors, consistent with their biological effects.

Question 12

What is magnolia bark extract good for?

Accepted Answer

Extracts from the bark of magnolia have been found to provide protective benefits against numerous neurological problems.

These cover not only brain diseases such as Alzheimer's disease, but also conditions such asanxiety, mood imbalances, and depression.

In a research involving 40 women aged between 20 and 50, it was discovered that taking 250 mg of a magnolia and phellodendron bark extract three times daily resulted in a substantial reduction in temporary and short-term anxiety compared to a placebo.

Another research of the same magnolia and phellodendron bark extract involving 56 adults found that a daily intake of 500 mg of the extract led to significantly reduced cortisol levels and improved mood.

Cortisol is your body's primary stress hormone. A decrease in cortisol indicates a reduction in overall stress.

However, it's worth noting that the supplement used in these studies included compounds other than just magnolia bark. This suggests that the observed effects cannot be solely attributed to the tree bark.

Lastly, a rodent study showed that a combination of honokiol and magnolol produced antidepressant-like effects, which included an increase in brain serotonin levels and a decrease in corticosterone levels in the blood.

Both corticosterone and serotonin play essential roles in regulating anxiety, mood, and depression.

Question 13

Who should not take magnolia bark?

Accepted Answer

Avoid using magnolia during pregnancy.

Diet Type	vegan, gluten free, vegetarian, halal
Item Form	capsule
Flavor	none
Unit Count	60
Monthly Supply	2 month

DHH-B Supplement - Bioactive Honokiol Magnolia Bark Extract

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DHH-B Supplement - Bioactive Honokiol Magnolia Bark Extract

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